Invasive mycoses: an emerging health threat
DOI:
https://doi.org/10.24197/cl.30.2025.99-105Keywords:
invasive mycoses, fungal infections, C.aurisAbstract
Unlike viral or bacterial infections, mycoses have been rather overlooked throughout history. However, in recent years, they have drawn increasing attention as a result of a significant rise in the incidence of these diseases and the challenges posed by their treatment, namely the emergence of drug resistances, the limited number of available antifungals, and the prevalence of serious comorbidities and immunosuppression among affected patients. As a result, the clinical outcome is usually unfavorable, with high mortality rates. Additionally, several factors currently at play are expected to further drive the rise of mycoses in the near future and lead to the emergence of new fungal pathogens, such as Candida auris, a yeast first identified in 2009 that is causing increasing alarm in the medical community and has been classified as a critical-priority threat in the WHO fungal priority pathogens list.
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Versalovic J, Carroll KC, Funke G, Jorgensen JH, Landry ML, Warnock DW. Manual of clinical microbiology: Tenth edition. Manual of Clinical Microbiology: Tenth Edition [Internet]. 2022 Jun 3 [cited 2025 Apr 12];1–2:1–2552. Available from: https://onlinelibrary-wiley-com.ponton.uva.es/doi/book/10.1128/9781555816728
WHO fungal priority pathogens list to guide research, development and public health action [Internet]. [cited 2025 Apr 12]. Available from: https://www.who.int/publications/i/item/9789240060241
Firacative C. Invasive fungal disease in humans: are we aware of the real impact? Mem Inst Oswaldo Cruz [Internet]. 2020 [cited 2025 Jul 29];115(9):e200430. Available from: https://pmc.ncbi.nlm.nih.gov/articles/PMC7546207/
Casadevall A. Fungal virulence, vertebrate endothermy, and dinosaur extinction: is there a connection? Fungal Genet Biol [Internet]. 2005 [cited 2025 Apr 20];42(2):98–106. Available from: https://pubmed.ncbi.nlm.nih.gov/15670708/
Paiva CN, Bozza MT. Are Reactive Oxygen Species Always Detrimental to Pathogens? Antioxid Redox Signal [Internet]. 2014 Feb 20 [cited 2025 Apr 13];20(6):1000. Available from: https://pmc.ncbi.nlm.nih.gov/articles/PMC3924804/
Denning DW. Global incidence and mortality of severe fungal disease. Lancet Infect Dis [Internet]. 2024 Jul 1 [cited 2025 Apr 12];24(7):e428–38. Available from: https://www.thelancet.com/action/showFullText?pii=S1473309923006928
The top 10 causes of death [Internet]. [cited 2025 Jul 29]. Available from: https://www.who.int/news-room/fact-sheets/detail/the-top-10-causes-of-death
Perlin DS, Rautemaa-Richardson R, Alastruey-Izquierdo A. The global problem of antifungal resistance: prevalence, mechanisms, and management. Lancet Infect Dis. 2017 Dec 1;17(12):e383–92.
Verweij PE, Arendrup MC, Alastruey-Izquierdo A, Gold JAW, Lockhart SR, Chiller T, et al. Dual use of antifungals in medicine and agriculture: How do we help prevent resistance developing in human pathogens? Drug Resist Updat [Internet]. 2022 Dec 1 [cited 2025 Apr 19];65:100885. Available from: https://pmc.ncbi.nlm.nih.gov/articles/PMC10693676/
Huang CJ, Lu MY, Chang YW, Li WH. Experimental Evolution of Yeast for High-Temperature Tolerance. Mol Biol Evol [Internet]. 2018 Aug 1 [cited 2025 Apr 19];35(8):1823–39. Available from: https://dx.doi.org/10.1093/molbev/msy077
Gusa A, Yadav V, Roth C, Williams JD, Shouse EM, Magwene P, et al. Genome-wide analysis of heat stress-stimulated transposon mobility in the human fungal pathogen Cryptococcus deneoformans. Proc Natl Acad Sci U S A [Internet]. 2023 Jan 24 [cited 2025 Apr 19];120(4). Available from: https://pubmed.ncbi.nlm.nih.gov/36669112/
Garcia-Bustos V. Is Candida auris the first multidrug-resistant fungal zoonosis emerging from climate change? mBio [Internet]. 2024 Apr 1 [cited 2025 Apr 19];15(4):e00146-24. Available from: https://pmc.ncbi.nlm.nih.gov/articles/PMC11005414/
Casadevall A, Kontoyiannis DP, Robert V. On the Emergence of Candida auris: Climate Change, Azoles, Swamps, and Birds. mBio [Internet]. 2019 [cited 2025 Apr 19];10(4). Available from: https://pubmed.ncbi.nlm.nih.gov/31337723/
Candida auris | Candida auris (C. auris) | CDC [Internet]. [cited 2025 May 1]. Available from: https://www.cdc.gov/candida-auris/index.html
García CS, Palop NT, Bayona JVM, García MM, Rodríguez DN, Álvarez MB, et al. Candida auris: descripción de un brote. Enferm Infecc Microbiol Clin [Internet]. 2020 Jan 1 [cited 2025 May 1];38:39–44. Available from: https://www.elsevier.es/es-revista-enfermedades-infecciosas-microbiologia-clinica-28-articulo-candida-auris-descripcion-un-brote-S0213005X20300379
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